5 Facts you should know about

WHIM syndrome

Its name is an acronym for its main clinical manifestations: warts, hypogammaglobulinemia, infections, and myelokathexis

Myelokathexis, sometimes known simply as kathexis, is a trapping or retention of immune cells in the bone marrow

The conditions are caused by mutations in the gene encoding the immune receptor CXC chemokine receptor 4 (CXCR4), causing it to be overactive

The first symptoms of the disorder usually present as recurring infections in early childhood, followed by the appearance of warts on various parts of the body

Susceptibility to HPV is disproportionate compared with other immunodeficiency conditions

See our full disease profile

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