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5 Facts you should know about
Antisense technology
1
In nature, antisense RNAs play a critical role in regulating gene expression at multiple levels, including replication, transcription, and translation
2
Antisense RNAs are unique DNA transcripts - they are small, noncoding, and diffusible molecules, containing 19–23 nucleotides that complement mRNA
3
After observing antisense-mediated RNA regulation in nature, researchers tested the feasibility of using synthetic antisense oligonucleotides to reduce levels of specific mRNA transcripts
4
Antisense oligonucleotides (ASOs) can bind to abnormal mRNA, preventing its translation into a harmful protein
5
By targeting the source of the pathogenesis, ASO-mediated therapies theoretically have a higher chance of success than therapies targeting downstream pathways
Rare Medical News
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